Kamyar Hadian

About

Work

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt
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Research Group Leader

Germany

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Publications

Erratum: Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening (Nature communications (2024) 15 1 DOI: 10.1038/s41467-024-55226-6.)

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Nature communications

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journal-article

The metabolic code of ferroptosis: nutritional regulators of cell death

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Trends in Biochemical Sciences

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journal-article

Scalable and universal prediction of cellular phenotypes

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bioRxiv

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other

Cyclosporine A in children with ABCA3 deficiency

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Pediatric Pulmonology

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journal-article

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

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Molecular Cell

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journal-article

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

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Nature Communications

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Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action

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JACS Au

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Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

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Nature Communications

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Seratrodast inhibits ferroptosis by suppressing lipid peroxidation

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Cell Death and Disease

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Scalable and universal prediction of cellular phenotypes enables in silico experiments

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preprint

The therapeutic potential of targeting regulated non-apoptotic cell death

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Nature Reviews Drug Discovery

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ABCA3 Deficiency—Variant-Specific Response to Hydroxychloroquine

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International Journal of Molecular Sciences

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journal-article

CellDeathPred: A Deep Learning framework for Ferroptosis and Apoptosis prediction based on cell painting

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bioRxiv

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other

CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting

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Cell Death Discovery

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journal-article

CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting

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Cell Death Discovery

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Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

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Nature Communications

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Reliability of High-Quantity Human Brain Organoids for Modeling Microcephaly, Glioma Invasion, and Drug Screening

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SSRN

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other

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening

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bioRxiv

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other

Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

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bioRxiv

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other

The therapeutic potential of targeting regulated non-apoptotic cell death

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Nature Reviews Drug Discovery

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journal-article

Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma

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European Journal of Medicinal Chemistry

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Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining

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ACS Chemical Biology

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Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining

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ACS Chemical Biology

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Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development

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Nature Structural & Molecular Biology

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Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development (Nature Structural & Molecular Biology, (2021), 28, 6, (521-532), 10.1038/s41594-021-00590-w)

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Nature Structural and Molecular Biology

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Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

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Cell Chemical Biology

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journal-article

Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis

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bioRxiv

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other

High-Content Screening Identifies Cyclosporin A as a Novel ABCA3-Specific Molecular Corrector

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American Journal of Respiratory Cell and Molecular Biology

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journal-article

Highly Accurate Filters to Flag Frequent Hitters in AlphaScreen Assays by Suggesting their Mechanism

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Molecular Informatics

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journal-article

Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity

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Current Protocols

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Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma

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Scientific Reports

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Unleashing high content screening in hit detection – Benchmarking AI workflows including novelty detection

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Computational and Structural Biotechnology Journal

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Vaccination versus SARS-CoV-2 Omicron: three vaccine doses win the battle

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Signal Transduction and Targeted Therapy

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Vaccination versus SARS-CoV-2 Omicron: three vaccine doses win the battle

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Signal Transduction and Targeted Therapy

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Inhalational Anesthetics Do Not Deteriorate Amyloid-β-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level

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Journal of Alzheimer's Disease

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Nuisance compounds in cellular assays

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Cell Chemical Biology

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A roadmap to creating ferroptosis-based medicines

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Nature Chemical Biology

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A roadmap to creating ferroptosis-based medicines

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Nature Chemical Biology

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Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns

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SLAS Discovery

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Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns

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SLAS Discovery

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Retinoic acid signaling is critical during the totipotency window in early mammalian development

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Nature Structural & Molecular Biology

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Retinoic acid signaling is critical during the totipotency window in early mammalian development

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Nature Structural and Molecular Biology

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journal-article

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

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British Journal of Pharmacology

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journal-article

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

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bioRxiv

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other

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

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Cell Stem Cell

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journal-article

Cilium induction triggers differentiation of glioma stem cells

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Cell Reports

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journal-article

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

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EMBO Molecular Medicine

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Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics

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Science Advances

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Studying OTUD6B-OTUB1 Protein–Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays

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Methods in Molecular Biology

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book-chapter

Erratum: Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 (Cell Stem Cell (2021) 28(9) (1566–1581.e8), (S1934590921001661), (10.1016/j.stem.2021.04.009))

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Cell Stem Cell

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journal-article

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

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Nature Communications

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GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

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ACS Central Science

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Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

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Nature Communications

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Cilium induction triggers differentiation of glioma stem cells

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bioRxiv

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other

Image-based high-content screening in drug discovery

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Drug Discovery Today

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journal-article

Image-based high-content screening in drug discovery

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Drug Discovery Today

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Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis

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Biochemistry

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Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q<inf>10</inf> Cooperatively Suppress Ferroptosis

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Biochemistry

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Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis

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Scientific Reports

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Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis

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Scientific Reports

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Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

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Nature Communications

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SnapShot: Ferroptosis

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Cell

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journal-article

Structure-Activity Relationship in Pyrazolo[4,3- c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity

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Journal of Medicinal Chemistry

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journal-article

Transferrin Receptor Is a Specific Ferroptosis Marker

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Cell Reports

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journal-article

Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers

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mBio

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journal-article

Inhibition of CPAP–tubulin interaction prevents proliferation of centrosome-amplified cancer cells

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EMBO Journal

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Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

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Journal of cell science

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A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor

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Journal of Biological Chemistry

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A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor

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Journal of Biological Chemistry

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E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression

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Journal of virology

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Luciferase Advisor: High-Accuracy Model to Flag False Positive Hits in Luciferase HTS Assays

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Journal of Chemical Information and Modeling

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journal-article

Reducing Mutant Huntingtin Protein Expression in Living Cells by a Newly Identified RNA CAG Binder

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ACS Chemical Neuroscience

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Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

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Journal of Biological Chemistry

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An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system

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Scientific Reports

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An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system

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Scientific Reports

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Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites

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Science

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Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites

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Science

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A high-content small molecule screen identifies novel inducers of definitive endoderm

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Molecular Metabolism

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journal-article

A high-throughput screening strategy for development of RNF8-Ubc13 protein-protein interaction inhibitors

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SLAS Discovery

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journal-article

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

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eLife

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A multiplexed high-content screening approach using the chromobody technology to identify cell cycle modulators in living cells

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Journal of Biomolecular Screening

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Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction

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Journal of Biomolecular Screening

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Inhibition of Canonical NF-κ B Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

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Scientific Reports

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journal-article

Meet our editorial board member

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Combinatorial Chemistry and High Throughput Screening

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journal-article

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

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Scientific Reports

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Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer

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Cancer Medicine

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A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

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BMC Cancer

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Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling

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Assay and Drug Development Technologies

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journal-article

In Vitro Detection of NEMO–Ubiquitin Binding using Delfia and Microscale Thermophoresis Assays

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Methods in Molecular Biology

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book

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

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Retrovirology

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journal-article

New small molecules targeting apoptosis and cell viability in osteosarcoma

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PLoS ONE

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journal-article

Identification of small-molecule frequent hitters from alphascreen high-throughput screens

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Journal of Biomolecular Screening

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journal-article

Protein-protein interaction modulator drug discovery: Past efforts and future opportunities using a rich source of low- and high-throughput screening assays

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Expert Opinion on Drug Discovery

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journal-article

Small molecule screening at helmholtz zentrum münchen - from biology to molecules

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Combinatorial Chemistry and High Throughput Screening

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journal-article

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts

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Virology Journal

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The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

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Molecular Cell

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journal-article

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

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Cancer Cell

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journal-article

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

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EMBO Journal

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NF-κB essential modulator (NEMO) interaction with linear and Lys-63 ubiquitin chains contributes to NF-κB activation

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Journal of Biological Chemistry

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Signals from the nucleus: Activation of NF-κB by cytosolic ATM in the DNA damage response

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Science Signaling

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Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp)

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AIDS

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journal-article

Ubiquitin conjugation and deconjugation in nf-κb signaling

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Sub-Cellular Biochemistry

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Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV rev protein

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Journal of Biological Chemistry

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journal-article

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

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Nature Cell Biology

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Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

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Experimental Cell Research

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Live-cell assay for simultaneous monitoring of expression and interaction of proteins

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BioTechniques

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The periplasmic E. coli chaperone Skp is a trimer in solution: Biophysical and preliminary crystallographic characterization

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Biological Chemistry

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